Black Seed Oil – is now being viewed by many oncologists as serious herbal remedy to assist in the treatment of cancer. The U.S. Food and Drug Administration has granted 2 patents that involve Nigella Sativa oil for treating cancer, preventing the side effects of chemotherapy, and for increasing the immune system functions in humans. U.S. Pat. No. 5,482,711 and 5,653,981.
In 1991, at the Amala Cancer Research Centre, Kerala, India, studies indicated that Nigella Sativa has efficacy as a chemotherapeutic agent. In other studies, it was found that the oil diminishes toxic side effects caused by several other chemotherapeutic drugs such as cisplatin and doxorubicin.
In 1997, at the Cancer Research Laboratory of Hilton Head Island, South Carolina, USA, it was proven that Nigella Sativa oil had enormous success in tumor therapy without the negative side effects of common chemo-therapy. They found that it increased the growth rate of bone marrow cells by a staggering 250% and it inhibited tumor growth by 50%. It stimulated immune cells and raised the interferon production which protects cells from the cell destroying effect of viruses. They confirmed the strongly anti-bacterial and anti-mycotic effects and they also confirmed that Nigella Sativa has an effect in lowering the blood sugar level which is essential for the treatment of diabetes. The report stated that a healthy immune system will detect and destroy cancer cells before the cancer endangers the patient, and concluded that the oil is an ideal candidate for use in cancer prevention and cure and that it has remarkable promises for clinical use.
In 2003, at the Jackson State University, USA, doctors interested to investigate why Nigella Sativa had been used for such a long time for the treatment of so many acute ailments studied its effectiveness in cancer prevention. They exposed breast cancer cells to Nigella Sativa extracts, and the cells were inactivated. Doctors concluded that it had promising results in the field of prevention and treatment of cancer.
Cancer of the Colon
In the same year doctors at the Osaka City University Medical School in Japan investigated the use of Nigella Sativa for the treatment of cancer of the colon. Their studies demonstrated that it inhibited the growth of cancer in the post- initiation stage.
In 2004, at the American University of Beirut, Lebanon, thymoquinone extracted from Nigella Sativa was investigated to see if it could terminate human colorectal cancer cells. Their studies revealed that thymoquinone has potential for the treatment of colon cancer.
In 1991, at the Amala Research Center in Amala Nagar, Kerala (India) studies confirmed the use of Nigella Sativa oil as an anti-tumor agent. Second common types of cancer cells, Dalton’s lymphoma ascites (DLA) cells, were also used. Mice which had received the EAC cells and Nigella Sativa remained normal without any tumor formation, illustrating that the active principle was 100% effective in preventing EAC tumor development.
Anti-fungal & Anti-bacterial Effects in the Treatment of Candida
In 2003, at the Aga Khan University Medical College, Karachi, Pakistan, the anti-fungal activity of Nigella Sativa was studied. Extracts from Nigella Sativa were found to have a considerable inhibitory effect on the growth of the Candida in all organs. They concluded that aqueous extract of Nigella Sativa exhibited inhibitory effect against candidiasis and that the traditional use of the plant in fungal infections was valid.
Studies with Pancreatic Cancer Cells
Nigella sativa helps treat a broad array of diseases, including some immune and inflammatory disorders. Previous studies also have shown anticancer activity in prostate and colon cancers, as well as antioxidant and anti-inflammatory effects. Using a human pancreatic cancer cell line, Dr Arafat and her team found that adding thymoquinone killed approximately 80 percent of the cancer cells. They demonstrated that thymoquinone triggered programmed cell death in the cells, and that a number of important genes, including p53, Bax, bcl-2 and p21, were affected. The researchers found that expression of p53, a tumor suppressor gene, and Bax, a gene that promotes programmed cell death, was increased, while bcl-2, which blocks such cell death, was decreased. The p21 gene, which is involved in the regulation of different phases of the cell cycle, was substantially increased. She presents her findings May 18 at the Digestive Disease Week in San Diego. Dr. Arafat and her co-workers also found that thymoquinone caused “epigenetic” changes in pancreatic cancer cells, modifying the cells’ DNA. She explains that these changes involve adding acetyl groups to the DNA structure, specifically to blocks of proteins called histones.
This “acetylation” process can be important for genes to be read and translated into proteins. In this case, it could involve the genes that are key to initiating programmed cell death. “We looked at the status of the histones and found surprisingly that thymoquinone increased the acetylation process,” Dr. Arafat says. “We never anticipated that.” At the same time, adding thymoquinone to pancreatic cancer cells reduced the production and activity of enzymes called histone deacetylases (HDACs), which remove the acetyl groups from the histone proteins, halting the gene transcription process. Dr. Arafat notes that HDAC inhibitors are a “hot” new class of drugs that interfere with the function of histone deacetylases, and is being studied as a treatment for cancer and neurodegenerative diseases. Finding that thymoquinone functions as an HDAC inhibitor, she says, “Was very remarkable and really exciting.” Link to article from Kimmel Cancer Center
More Pancreatic Cancer Studies
Both hereditary and sporadic forms of chronic pancreatitis are associated with an increased risk of developing pancreatic ductal adenocarcinoma (PDA). Inflammation has been identified as a significant factor in the development of solid tumour malignancies. We have recently shown that thymoquinone (Tq), the major constituent of Nigella sativa oil extract, induced apoptosis and inhibited proliferation in PDA cells. Tq also increased p21 WAF1 expression, inhibited histone deacetylase (HDAC) activity, and induced histone hyperacetylation. HDAC inhibitors have been shown to ameliorate inflammation-associated cancer. In this study, we evaluated the anti-inflammatory potential of Tq in PDA cells in comparison with that of a specific HDAC inhibitor, trichostatin A (TSA).
Herbal therapies are commonly used for the prevention and treatment of cancer, although we have little understanding of their molecular and cellular bases of action. Nigella sativa is an herb used in traditional medicine in many Middle Eastern and Asian countries to treat a broad array of diseases. Thymoquinone (Tq) (2-isopropyl-5-methyl-1,4-benzoquinone), the most abundant constituent of the seed oil extract, has been shown to have anti-neoplastic activities in different types of cancer. Tq also has cytoprotective effects that are mainly mediated through its antioxidant and anti-inflammatory activities. Despite Tq’s interesting potential as an anti-neoplastic agent, its anti-inflammatory effects in PDA cells have not been evaluated. We have recently shown that Tq reduces PDA cell growth and promotes apoptosis through increasing the Bax-Bcl-2 ratio, activating capase-3, and inhibiting histone deacetylase (HDAC) activity and transcription.30 In this study, we evaluated the anti-inflammatory potential of Tq in PDA cells in comparison with a specific HDAC inhibitor, trichostatin A (TSA).
Black Seed Oil Protocol:
Take 1 teaspoon of Black Seed Oil mixed with ½ teaspoon of Raw Manuka Honey taken ½ hour before breakfast.
1 teaspoon of the oil mixed with the juice of 1 orange, or you can substitute the oil with 1 tsp of black seed powder mixed with the juice of one orange. This is taken in the afternoon.
1 teaspoon of oil mixed with ½ teaspoon of Raw Manuka Honey taken before bed.
Dark, raw honey such as Manuka has its own healing qualities and is used as a carrier for the oil in this therapy.
Combine this with a healthy lifestyle and an anti-cancer diet which is found at the top of this post.
Latest posts by admin (see all)
- 5 Proven Tips To Prevent Your Lips From Darkening - August 2016
- Try the Cucumber Diet and Lose 7kg in 14 Days - August 2016
- You Have Lost Part of Your Hair? Here is How to Grow Out Your Hair Faster - August 2016